With over a decade behind it, you have to make the argument that "The Ultimates" by Mark Millar and Bryan Hitch is the most culturally significant comic book story so far this century. It reads like a movie blueprint, and - while its eventual adaptation for the big screen was not note-for-note - many of the Marvel heroes we see on the big screen today are influenced more by the incarnations seen here than the ones who had been around for decades previous.
